Effect of Corticosteroids on Acrylamide Monomer Toxicity

Abstract

Acrylamide (ACR) is a chemical used in many industries around the world and more recently was found to form naturally in foods cooked at high temperatures. Acrylamide was shown to be a neurotoxicant, reproductive toxicant, and carcinogen in animal species. Only the neurotoxic effects were observed in humans and only at high levels of exposure in occupational settings. The mechanism underlying neurotoxin effects of ACR may be basic to the other toxic effects seen in animals. This mechanism involves interference with the kinesin-related motor proteins in nerve cells or with fusion proteins in the formation of vesicles at the nerve terminus and eventual cell death. This study was undertaken to study the effect of acrylamide monomer on catecholamine and the results support experimental findings reported in the literature. 50 cases of effect of corticosteroids by acrylamide were studied in rats. Rats were treated with acrylamide (37.5 mg/kg) at an interval of 7, 15 and 29 days respectively. Both immunized and nonimmunized groups were studied. Changes were observed both in nonimmunized and immunized animals. The present study stresses the acute and chronic effects of acrylamide on corticosteroids and the results support experimental findings reported in the literature. Sensitive methods for evaluating the effect of acrylamide on corticosteroids and allergic manifestation are required .Finally methods must also be evolved to delineate the effects produced by acrylamide per se and its metabolic intermediaries. ACR is known to influence autonomic nervous system and hence the changes observed in corticosteroids may be due to a shift in the fine balance between these two systems.

Keywords: ACRt–Acrylamide treated, ACR-I–Acrylamide treated Immunized