Down’s Syndrome (DS): A Genetic Disorder

Abstract

Down’s syndrome (DS) is a chromosomal disorder which occurs due to an error in cell division subsequently leading to an extra 21st chromosome. DS or trisomy 21 is a condition where an individual has 47 chromosomes in each cell instead of 46. It is a multisystem disorder as it affects more than one system of our body. As a consequence, impairments in both cognitive ability and physical growth take place that range from mild to moderate developmental disabilities. It is the most common genetic disorder and the probability of occurrence of this syndrome is 1/660 births. John Langdon Down was first to identify this syndrome. Factors like advance maternal age, deficiency of folic acid during pregnancy, etc., increase the risk of baby with DS.

Keywords: Down’s syndrome, chromosomal mutation, translocation, therapeutic strategy

Cite this Article

Kumari Nimisha. Down’s Syndrome (DS): A Genetic Disorder. Research and Reviews: Journal of Immunology (RRJoI). 2015; 5(2): 21–26p.