An Update on the Virulence Factors of Actinobacillus Actinomycetemcomitans - A Systematic Review

Autores/as

  • Shikha Kler DAV (C) Dental College and Hospital, YamunaNagar, Haryana- 135001
  • Rajvir Malik DAV (C) Dental College and Hospital, Yamunanangar, Haryana- 135001

Palabras clave:

Adhesions, Collagenase, Genes, Leucotoxin, Surface-associated material

Resumen

Over the last 20 years, research on Actinobacillus acti­nomycetemcomitans (Aa) a periodontopathogen, has provided a tremendous amount of information as a major anaerobic, opportunistic pathogen. Elucidation of the virulence in Aa is especially difficult because of this bacterium’s pathogenicity being multifaceted, including both microbial and host fac­tors and the inability to clearly define the disease state of many forms of destructive periodontal dis­ease. The objectives of this study were to review the virulence factors of Aa considering the unique features of Aa when compared with other gram-negative bacteria and explicate the general aspects of the virulence factors of Aa and their mechanism in particular. A comprehensive search strategy of electronic databases (MEDLINE, EMBASE, The Cochrane Central Register of Controlled Trials, the U.K. National Research Register and Conference Proceedings Citation Index) using key words was performed. In addition, hand searches were made for several dental, microbiological and immunity journals not cataloged in the databases, and the reference lists from published articles were checked. It was concluded that virulence factors of Aa allows it to make contact with host tissues and cells, which are potentially important in the incidence of periodontal diseases.

Biografía del autor/a

  • Shikha Kler, DAV (C) Dental College and Hospital, YamunaNagar, Haryana- 135001
    Senior LecturerDepartment of Oral and MaxilloFacial Pathology
  • Rajvir Malik, DAV (C) Dental College and Hospital, Yamunanangar, Haryana- 135001
    Associate ProfessorDepartment of Periodontology and Implantology

Descargas

Publicado

2010-11-30

Número

Vol. 1 Núm. 1 (2010)

Sección

Review Articles

Licencia

Declaration and Copyright Transfer Form

(to be completed by authors)

I/ We, the undersigned author(s) of the submitted manuscript, hereby declare, that the above manuscript which is submitted for publication in the STM Journals(s), is not published already in part or whole (except in the form of abstract) in any journal or magazine for private or public circulation, and, is not under consideration of publication elsewhere.

·         I/We will not withdraw the manuscript after 1 week of submission as I have read the Author Guidelines and will adhere to the guidelines.

·         I/We Author(s ) have niether given nor will give this manuscript elsewhere for publishing after submitting in STM Journal(s).

·         I/ We have read the original version of the manuscript and am/ are responsible for the thought contents embodied in it. The work dealt in the manuscript is my/ our own, and my/ our individual contribution to this work is significant enough to qualify for authorship.

·          I/We also agree to the authorship of the article in the following order:

Author’s name                                    

 

1. ________________

2. ________________

3. ________________

_______________

We  Author(s) tick this box and would request you to consider it as our signature as we agree to the terms of this Copyright Notice, which will apply to this submission if and when it is published by this journal.