Effect of Beta Asarone–The Active Principle of Acorus Calamus in Neuroprotection and Nerve Cell Regeneration on the Pyramidal Region of Hippocampus in Mesial Temporal Lobe Epileptic Rat Models

Abstract

Epilepsy is a common chronic neurological disorder with seizures. About 1% of people worldwide (65 million) have epilepsy and nearly 80% of cases occur in developing countries [1]. MTLE is the major form of focal epilepsy associated with hippocampal atrophy or sclerosis. For this study we produced a model of mesial temporal epilepsy sterotaxically by inducing kainic acid into the right hippocampus. For this study animals were divided into seven groups CO, LC-2, AC35-2, BA20-2, LC-7, AC35-7 and BA20-7, all the animals except CO group were undergone the lesion surgery. The groups AC35 and BA20 were given ethanolic extract of acorus calamus 35 mg/kg body weight and beta asarone 20 mg/kg body weight accordingly. After lesion surgery the lesion control animals exhibited epileptic seizure but the drug group animals have not shown any epileptiform activity. Histological studies were done on both 2nd and 7th day to find out the neuro protective and neuro regenerative ability of the drug employed and they proved the neuro protective and regenerative ability of both the drugs but with an add on effect with beta asarone. 

Keywords: AC=Calamus oil, BA=Beta Asarone, CO=Control, LC=Lesion control, LD 50=Lethal dose 50, IP=Intraperitoneal, MTLE=Mesial Temporal Lobe Epilepsy

Cite this Article

Venkatramaniah C, Mary Antony Praba A. Effect of Beta Asarone–The Active Principle of Acorus Calamus in Neuroprotection and Nerve Cell Regeneration on the Pyramidal Region of Hippocampus in Mesial Temporal Lobe Epileptic Rat Models. Research and Reviews: Journal of Neuroscience (RRJoNS). 2015; 5(1): 19–24p.