Analysis for Respiratory Transmittable Diseases via Mass Spectrometry

Abstract

Microbial identification in clinical diagnostic laboratories has mainly relied on conventional phenotypic and gene sequencing identification techniques. The development of matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) devices has revolutionized the repetitive identification of microorganisms in clinical microbiology laboratories by introducing an easy, rapid, high throughput, low-cost, and effective identification technique. This technology has been modified to the restraint of clinical diagnostic laboratories and has likely to replace or complement conventional identification techniques for both bacterial and fungal strains. In recent advances of MALDI-TOF-MS as the laboratory diagnostic tool for the rapid laboratory diagnosis of microorganisms associated with respiratory infectious diseases, with the focus on rapid identiï¬cation of pathogenic bacteria and molecular markers discovery using MALDI-TOF-MS. With the advanced technologies such as MALDI-TOF, early and targeted therapies are based on rapid identification of pathogens and could lead to quick and effective treatment of respiratory infections and better patient management.

Keywords: Respiratory infectious diseases, rapid laboratory diagnosis, pathogenic bacteria

Cite this Article

Kriti Gupta. Analysis for Respiratory Transmittable Diseases via Mass Spectrometry. Research & Reviews: Journal of Microbiology and Virology. 2017; 7(1): 26–30p.