Anti-Ulcer Activity of Methanolic Extract of Mucuna Pruriens Seed on Indomethacin Induced Ulcers in Albino Rats

Abstract

The present study was intended to investigate and evaluate the antiulcer activity of the methanol seed extract of Mucuna pruriens using indomethacin induced ulcer in albino rats and to determine its link between oxidant or antioxidant parameter. The extract of Mucuna pruriens was tested on indomethacin induced gastric ulcer in albino rats. The antiulcer activity of high dose (400 mg/kg) and low dose (200 mg/kg) of ethanolic extract of Mucuna pruriens was assessed by measuring the ulcerative area and percentage reduction of ulcerative area, which was compared with a standard drug misoprostol. To determine the underlying mechanism for its antiulcer activity, the oxidant/antioxidant parameters like glutathione peroxidase (GPO), superoxide dismutase (SOD), catalase (CAT), myeloperoxidase (MPO), malondialdehyde (MDA) and glutathione (GSH) enzyme were measured in the gastric tissues. Pretreatment of ethanolic extract both high dose and low dose showed significant (p<0.001) decrease in the ulcerative area as compared to the control and was almost as effective as the standard misoprostol. In rats given ethanolic extract, all of the investigated antioxidant parameters increased, except for catalase (CAT). Conversely, aside from myeloperoxidase (MPO), all oxidant parameters decreased. In conclusion, the antiulcer activity of Mucuna pruriens may be due to its antioxidant property.

Keywords: Mucuna pruriens, indomethacin induced ulcer, ulcer area, superoxide dismutase, catalase, glutathione

Cite this Article

Iswar Hazarika, Panner Selvam, Anju Das. Anti-Ulcer Activity of Methanolic Extract of Mucuna Pruriens Seed on Indomethacin Induced Ulcers in Albino Rats. Research & Reviews: A Journal of Life Sciences. 2015; 5(2): 1–8p.