Assessment of Serum Enzymes Level in Patients with Thyroid Alteration Attending Manipal Teaching Hospital, Pokhara

Abstract

Thyroid hormones exert their effect on all tissue and modulate the rate of metabolic activity. Alterations in thyroid function can affect the various organ system of body and perturb measures like AST, ALT, GGT, ALP, CPK and LDH. Both hypothyroidism and hyperthyroidism have potentially fatal systemic manifestations. The main aim of study was to determine the relationship between thyroid alteration and serum enzymes level. The study included 110 subjects visiting Endocrinology Unit of Department of Biochemistry, MTH, Pokhara, with the request of TFT. Thyroid profile and serum enzymes were analyzed using standard kits. Each thirty hyperthyroid and hypothyroid cases show slight elevation of AST, ALT and GGT. However, the values were higher in hyperthyroid subjects. ALP, CPK and LDH were markedly elevated both in hyperthyroidism and hypothyroidism as compared to controls. In conclusion, conducted  study demonstrated that there is a positive association between increased serum AST, ALT, GGT, CPK, ALP and LDH in hyperthyroidism and hypothyroidism.