New Topics in Serum Copeptin Levels in Hypertension: Is There an Interrelation with Inflammatory Biomarkers?

Abstract

This study aimed to test the hypothesis that the link between serum copeptin (Cop) levels and hypertension is related to low grade of inflammation and atherosclerosis indices. This observational cross section study was done in the Department of Biology, College of Science at the University of Al-Mustansiriya in Baghdad, Iraq.  A total number of 18 healthy subjects (Group I) and 66 patients (Group II) were enrolled in this study. Patients who were on the antihypertensive medications and have a blood pressure of < 140 mmHg (systolic) and < 90 mmHg (diastolic) were considered controlled hypertension (Group IIA), patients who were on the antihypertensive medications and have a blood pressure of ≥140 mmHg (systolic) and < 90 mmHg (diastolic) were considered as isolated hypertension (Group IIB) and patients who were on the antihypertensive medications and have a blood pressure of ≥140 mmHg (systolic) and ≥90 mmHg (diastolic) were considered as uncontrolled hypertension (Group IIC). The following determinants were measured: blood pressure, anthropometric measurements, fasting serum lipid profile, C-reactive protein (CRP), serum copeptin (Cop) levels, and the monocytes number to high density lipoprotein-cholesterol (M/HDL-c) ratio was calculated. Our results showed thatsignificant differences were observed in the demographic characteristics between studied. Forty (60.6%) hypertensive patients were positively reacted to CRP test (> 6 mg/L). The mean ± SD of M/HDL-c ratio were significantly (P<0.001) lower in Group IIB (6.7±3.0) compared with Group I (8.2±3.1). The mean value of serum (Cop) of Group IIA (171.4 ng/L) was non-significantly (P>0.05) higher than Group I (127.5 ng/L), Group IIB (102.3 ng/L) and Group IIC (131.8 ng/L).  There was a non-significant association between positive reaction of CRP and the mean values of serum (Cop) in group II patients as well as non-significant (P>0.05) correlations between serum (Cop) levels with M/HDL-c ratio were observed in Group I (r = -0.107), Group IIA (r = -0.025), Group IIB (r = -0.119) and Group IIC (r = +0.022).  We conclude that the alterations of serum (Cop) levels in hypertension do not show significant association with CRP or correlations with M/HDL-c ratio as inflammatory markers.

Keywords: Hypertension, copeptin, C-reactive protein, lipid profile, monocytes number to high density lipoprotein ratio

Cite this Article

Marwan S.M. Al-Nimer, Majid M. Mahmood, Rawia M. Al-Nuaemy. New Topics in Serum Copeptin Levels in Hypertension: Is There an Interrelation with Inflammatory Biomarkers? Research & Reviews: Journal   of Immunology.       2016;     6(2): 20–28p.