Over Expression of Genes at Long Arm of 21 Chromosome in Case of Down Syndrome

Abstract

Down Syndrome (DS) is a genetic disorder which is caused due to trisomy at chromosome 21 or gene dosage imbalance. DS leads to mental retardation in humans. It is a multisystem disorder as it affects several systems of our body like cardiovascular, respiratory, gastrointestinal, neurological, hematopoietic and musculoskeletal system. The principal cause of DS is unknown yet. Some factors are responsible for DS. like reproduction at advanced maternal age, folic acid deficiency, consanguineous marriages, etc. MTRR, MTHFR, Has 21, DYRK1A, APP, SOD, etc., have effect during occurrence of DS.

Keywords: Down Syndrome (DS), factors affecting DS, milestones of research, mutation

Cite this Article

Kumari Nimisha. Over Expression of Genes at Long Arm of 21 Chromosome in Case of Down Syndrome. Research and Reviews: Journal of Immunology (RRJoI). 2015; 5(2): 27–34p.